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The power to resist: the relationship between power, stigma, and negative symptoms in schizophrenia.
Stigmatizing beliefs about mental illness can be a daily struggle for people with schizophrenia. While investigations into the impact of internalizing stigma on negative symptoms have yielded mixed results, resistance to stigmatizing beliefs has received little attention. In this study, we examined the linkage between internalized stigma, stigma resistance, negative symptoms, and social power, or perceived ability to influence others during social interactions among people with schizophrenia. Further, we sought to determine whether resistance to stigma would be bolstered by social power, with greater power in relationships with other possibly buffering against motivation/pleasure negative symptoms. Fifty-one people with schizophrenia or schizoaffective disorder completed measures of social power, internalized stigma, and stigma resistance. Negative symptoms were assessed using the Clinical Assessment Interview for Negative Symptoms (CAINS). Greater social power was associated with less internalized stigma and negative symptoms as well as more stigma resistance. Further, the relationship between social power and negative symptoms was partially mediated by stigma resistance. These findings provide evidence for the role of stigma resistance as a viable target for psychosocial interventions aimed at improving motivation and social power in people with schizophrenia
Some non perturbative calculations on spin glasses
Models of spin glasses are studied with a phase transition discontinuous in
the Parisi order parameter. It is assumed that the leading order corrections to
the thermodynamic limit of the high temperature free energy are due to the
existence of a metastable saddle point in the replica formalism. An ansatz is
made on the form of the metastable point and its contribution to the free
energy is calculated. The Random Energy Model is considered along with the
p-spin and the p-state Potts Models in their p < infinity expansion.Comment: 12 pages, LaTe
Dynamical fluctuations in an exactly solvable model of spin glasses
In this work we calculate the dynamical fluctuations at O(1/N) in the low
temperature phase of the spherical spin glass model. We study the
large-times asymptotic regimes and we find, in a short time-differences regime,
a fluctuation dissipation relation for the four-point correlation functions.
This relation can be extended to the out of equilibrium regimes introducing a
function which, for large time , we find scales as as in
the case of the two-point functions.Comment: Latex, 8 page
Complexity and line of critical points in a short-range spin-glass model
We investigate the critical behavior of a three-dimensional short-range spin
glass model in the presence of an external field \eps conjugated to the
Edwards-Anderson order parameter. In the mean-field approximation this model is
described by the Adam-Gibbs-DiMarzio approach for the glass transition. By
Monte Carlo numerical simulations we find indications for the existence of a
line of critical points in the plane (\eps,T) which separates two
paramagnetic phases and terminates in a critical endpoint. This line of
critical points appears due to the large degeneracy of metastable states
present in the system (configurational entropy) and is reminiscent of the
first-order phase transition present in the mean-field limit. We propose a
scenario for the spin-glass transition at \eps=0, driven by a spinodal point
present above , which induces strong metastability through Griffiths
singularities effects and induces the absence of a two-step shape relaxation
curve characteristic of glasses.Comment: 5 pages, 4 postscript figure, revte
Finite dimensional corrections to mean field in a short-range p-spin glassy model
In this work we discuss a short range version of the -spin model. The
model is provided with a parameter that allows to control the crossover with
the mean field behaviour. We detect a discrepancy between the perturbative
approach and numerical simulation. We attribute it to non-perturbative effects
due to the finite probability that each particular realization of the disorder
allows for the formation of regions where the system is less frustrated and
locally freezes at a higher temperature.Comment: 18 pages, 5 figures, submitted to Phys Rev
Glass transition in the quenched and annealed version of the frustrated lattice gas model
In this paper we study the 3d frustrated lattice gas model in the annealed
version, where the disorder is allowed to evolve in time with a suitable
kinetic constraint. Although the model does not exhibit any thermodynamic
transition it shows a diverging peak at some characteristic time in the
dynamical non-linear susceptibility, similar to the results on the p-spin model
in mean field and Lennard-Jones mixture recently found by Donati et al.
[cond-mat/9905433]. Comparing these results to those obtained in the model with
quenched interactions, we conclude that the critical behavior of the dynamical
susceptibility is reminiscent of the thermodynamic transition present in the
quenched model, and signaled by the divergence of the static non-linear
susceptibility, suggesting therefore a similar mechanism also in supercooled
glass-forming liquids.Comment: 8 pages, 14 figure
Integration of linear and dendritic actin nucleation in Nck-induced actin comets
The Nck adaptor protein recruits cytosolic effectors such as N-WASP that induce localized actin polymerization. Experimental aggregation of Nck SH3 domains at the membrane induces actin comet tails-dynamic, elongated filamentous actin structures similar to those that drive the movement of microbial pathogens such as vaccinia virus. Here we show that experimental manipulation of the balance between unbranched/branched nucleation altered the morphology and dynamics of Nck-induced actin comets. Inhibition of linear, form-in-based nucleation with the small-molecule inhibitor SMIFH2 or overexpression of the formin FH1 domain resulted in formation of predominantly circular-shaped actin structures with low mobility (actin blobs). These results indicate that formin-based linear actin polymerization is critical for the formation and maintenance of Nck-dependent actin comet tails. Consistent with this, aggregation of an exclusively branched nucleation-promoting factor (the VCA domain of N-WASP), with density and turnover similar to those of N-WASP in Nck comets, did not reconstitute dynamic, elongated actin comets. Furthermore, enhancement of branched Arp2/3-mediated nucleation by N-WASP overexpression caused loss of the typical actin comet tail shape induced by Nck aggregation. Thus the ratio of linear to dendritic nucleation activity may serve to distinguish the properties of actin structures induced by various viral and bacterial pathogens.Fil: Surtayeva, Sofya. University of Connecticut School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Velle, Katrina B.. University of Connecticut; Estados UnidosFil: Campellone, Kenneth G.. University of Connecticut; Estados UnidosFil: Talman, Arthur. Yale School of Medicine; Estados UnidosFil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San MartÃn. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Agaisse, Hervé. Yale School of Medicine; Estados UnidosFil: Wu, Yi I.. University of Connecticut School of Medicine; Estados UnidosFil: Loew, Leslie M.. University of Connecticut School of Medicine; Estados UnidosFil: Mayer, Bruce J.. University of Connecticut School of Medicine; Estados Unido
Self Consistent Screening Approximation For Critical Dynamics
We generalise Bray's self-consistent screening approximation to describe the
critical dynamics of the theory. In order to obtain the dynamical
exponent , we have to make an ansatz for the form of the scaling functions,
which fortunately can be much constrained by general arguments. Numerical
values of for , and are obtained using two different
ans\"atze, and differ by a very small amount. In particular, the value of obtained for the 3-d Ising model agrees well with recent
Monte-Carlo simulations.Comment: 21 pages, LaTeX file + 4 (EPS) figure
Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation
Upon infection of mammalian cells, enterohemorrhagic E. coli (EHEC) O157:H7 utilizes a type III secretion system to translocate the effectors Tir and EspFU (aka TccP) that trigger the formation of F-actin-rich ‘pedestals’ beneath bound bacteria. EspFU is localized to the plasma membrane by Tir and binds the nucleation-promoting factor N-WASP, which in turn activates the Arp2/3 actin assembly complex. Although N-WASP has been shown to be required for EHEC pedestal formation, the precise steps in the process that it influences have not been determined. We found that N-WASP and actin assembly promote EHEC-mediated translocation of Tir and EspFU into mammalian host cells. When we utilized the related pathogen enteropathogenic E. coli to enhance type III translocation of EHEC Tir and EspFU, we found surprisingly that actin pedestals were generated on N-WASP-deficient cells. Similar to pedestal formation on wild type cells, Tir and EspFU were the only bacterial effectors required for pedestal formation, and the EspFU sequences required to interact with N-WASP were found to also be essential to stimulate this alternate actin assembly pathway. In the absence of N-WASP, the Arp2/3 complex was both recruited to sites of bacterial attachment and required for actin assembly. Our results indicate that actin assembly facilitates type III translocation, and reveal that EspFU, presumably by recruiting an alternate host factor that can signal to the Arp2/3 complex, exhibits remarkable versatility in its strategies for stimulating actin polymerization
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